Azithromycin loaded polyethylene sebacate nanoparticles preparation, Essay

Azithromycin loaded polyethylene sebacate nanoparticles preparation, pharmacokinetic and efficacy in pneumonia of rabbits - Essay Example The reason for the interest is that the scientific community believes that there are 2 ways of using nanoparticles for drug delivery. The first reason is that due to the minute size of the particle, nanoparticles have the uncanny ability to penetrate even the smallest human capillary. The nanoparticles spread through the human system, thus allowing for efficient drug accumulation in target specific areas of the body. Second, the biodegradable materials used in the creation of nanoparticles has allowed pharmaceutical companies to develop long term release drug preparations within target sites covering a span of a few days to a few weeks. (Sahoo et al., 2003) The reason for this superior method of chemical delivery within the human system stems from the nanomedicines measuring only between 10 and 100 nanometers (nm). This makes the chemicals much easier to absorb than its larger sized counterparts when administered in passive mode for tissue penetration. Currently, nanomedicine drug formulations are designed to work with existing generic drugs, which reduces the cost of drug formulation for the pharmaceutical company. While most drugs in its current form are already effective in treating various illnesses, nano formulation of the same drugs allow the manufacturers to fine tune the drug molecules, this providing a significant increase in the effectiveness of the drug. This is done through the development of sustained release drugs that offer minimal side effects in the process. Known as nanoparticular drug delivery, the system allows a normal pharmacokinetic profile to deliver the correct amount of drugs in a targeted method that will affect only the required area over an extended period. This is a method that is not totally possible with encapsulated drugs. The nanoparticular drug delivery has allowed pharmaceutical science to